Loss of RAGE defense: a cause of Charcot neuroarthropathy?
作者： K. A. Witzke , A. I. Vinik , L. M. Grant , W. P. Grant , H. K. Parson
DOI: 10.2337/DC10-2315
关键词: Arthropathy 、 Endocrinology 、 Peripheral 、 Diabetes mellitus 、 Bone mineral 、 Glycation 、 Medicine 、 Internal medicine 、 Calcaneus 、 Bone remodeling 、 Osteocalcin 、 Urology
摘要: OBJECTIVE This study investigated the relationship between circulating soluble receptor for advanced glycation end products (sRAGE) and parameters of bone health in patients with Charcot neuroarthropathy (CNA). RESEARCH DESIGN AND METHODS Eighty men (aged 55.3 ± 9.0 years), including 30 healthy control subjects, type 2 diabetic without Charcot, 20 stage (nonacute) CNA, underwent evaluations peripheral autonomic neuropathy, nerve conduction, markers turnover, mineral density, stiffness calcaneus. RESULTS CNA had worse neuropathy a lower index than or individuals (77.1, 103.3, 105.1, respectively; P > 0.05). subjects also sRAGE levels (162 vs. 1,140 pg/mL; CONCLUSIONS significantly sRAGE, an accompanying increase serum reduced calcaneus not accompanied by reductions density. These data suggest failure RAGE defense mechanisms against oxidative stress diabetes. Future studies should determine if medications that activity could be useful mitigating progression to CNA.
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