In diabetic Charcot neuroarthropathy impaired microvascular function is related to long lasting metabolic control and low grade inflammatory process.
作者： Aleksandra Araszkiewicz , Jacek Soska , Katarzyna Borucka , Marta Olszewska , Pawel Niedzwiecki
DOI: 10.1016/J.MVR.2015.07.008
关键词:
摘要: Abstract Aims The aim of this study was to assess microvascular function associated with the occurrence Charcot neuroarthropathy (CN) in patients diabetes. Methods We evaluated 70 diabetic (54 men) (CN-DM), median age 59 (IQR: 51–62), mean disease duration 16 ± 8 years. control group were subjects diabetes and without (DM), 54 men, 60 (54–62), 15 ± 7 years. assessed metabolic diabetes, serum C-reactive protein concentration (CRP) cardiovascular autonomic neuropathy (CAN). used AGE-Reader measure skin autofluorescence (AF) accumulation advanced glycation end products that reflects long lasting control. Microvascular examined by laser Doppler flowmetry (PERIFLUX 5000) thermal hyperemia (TH) postocclusive reactive (PORH). Results CN-DM as compared DM had lower HbA1c level [7.6 (6.6–8.4) vs 8.4 (7.3–9.7)%, p Conclusion Deterioration system dysfunction are present neuroarthropathy. Impaired reactivity is worse low grade inflammatory process.
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