Relationship between peripheral diabetic neuropathy and microvascular reactivity in patients with type 1 and type 2 diabetes mellitus : Neuropathy and microcirculation in diabetes

摘要: The aim of the study was to evaluate differences in relationship between peripheral diabetic neuropathy and microvascular reactivity type 1 2 patients. Twenty-eight 37 patients were included study. Control groups consisted 18 25, age body mass index matched healthy persons. presence estimated by vibration perception threshold higher than 20 V evaluated biothesiometry. Microvascular examined laser doppler fluxmetry using postocclusive reactive hyperemia thermal hyperemia. following variables vascular examined: peak flow after occlusion as a difference maximal basal perfusion (PORH (max)), mean velocity increase during (max)/t (1)), (TH (max)) (2)). These parameters are expressed units (PU) or per second (PU . s (-1)). without evidence comparable with that persons it significantly all tested (max): 64 [40; 81] PU vs. 24 [17; 40] PU, p < 0.001, PORH (1): 5.41 [2.69; 8.18] PU/s 1.21 [0.69; 2.5] PU/s, TH 105 [77; 156] 56 [46; 85] 0.001 (2): 2.48 [1.67; 3.33] 0.87 [0.73; 1.06] 0.001). On contrary, no found 48 [30; 60] 49 [36; 57] NS, 3.46 [2.15; 5.19] 3.29 [2.45; 4.8] 95 [78; 97 [73; 127] NS 1.45 [0.95; 2.84] 1.37 [1.12; 1.95] NS). In both these BMI An inverse observed vibratory patients, but not true We suppose pathogenesis impaired may be differently influenced metabolic factors