AAPM recommendations on dose prescription and reporting methods for permanent interstitial brachytherapy for prostate cancer: Report of Task Group 137

摘要: During the past decade, permanent radioactive source implantation of prostate has become standard care for selected cancer patients, and the techniques have evolved in many different forms. Although most implants use I 125 or P 103 d sources, clinical use C 131 s sources has also recently been introduced. These sources produce dose distributions irradiate tumors at different dose rates. Ultrasound was used originally to guide planning sources tumor. More recently, CT and/or MR are used routinely clinics evaluation planning. Several investigators reported that the tumor volumes and target volumes delineated from ultrasound, CT, can vary substantially because inherent differences these imaging modalities. It has depend critically on time after the implant. Many clinics, particular those using intraoperative implantation, perform imaging only day implant. Because effects edema caused by surgical trauma one patient another resolve rates, timing of imaging for dosimetry evaluation can a profound effect (to delivered), i.e., same implant (same dose delivered), CT at different yield doses reported. Also, loading patterns and margins around tumor used, may lead variations the dose delivered. In this report, current literature issues is reviewed, impact of these radiobiological response estimated. The radiobiological models the biological equivalent (BED) are reviewed. Starting with BED model acute single doses, the models for fractionated doses, continuous low-dose-rate irradiation, both homogeneous and inhomogeneous dose distributions, as well cure probability models, Based developments in literature, AAPM recommends guidelines prescription physics perspective routine patient treatment, trials, treatment software developers. authors continue follow recommendations D 90 and V 100 as primary quantities, more specific on the modalities imaging. AAPM recommends postimplant should be performed optimum for specific radionuclides. In addition, they encourage radiobiological model a specific set parameters facilitate relative comparisons plans reported by institutions or