Surface coating for prevention of metallic seed migration in tissues.

摘要: Purpose: In radiotherapy, metallic implants often detach from their deposited sites and migrate to other locations. This undesirable migration could cause inadequate dose coverage for permanent brachytherapy difficulties in image-guided radiation delivery patients. To prevent of implanted seeds, the authors propose a potential strategy use biocompatible tissue-adhesive material called polydopamine. Methods: this study, nonradioactive dummy seeds that have same geometry composition as commercial I-125 were coated Using scanning electron microscopy x-ray photoelectron spectroscopy, surface polydopamine-coated noncoated was characterized. The detachment stress between two types tissue measured. efficacy seed investigated through vitro tests by tracing location after implantation shaking given times. cytotoxicity polydopamine coating also evaluated. Results: results characterization shown successfully on seeds. adhesion test, had 2.1-fold greater than From it determined migrated shorter distances seed. differencemore » increased with length time implantation. Conclusions: suggest is an effective technique especially prostate brachytherapy.« less