Effect of Cyclodextrins on Topical Drug Delivery to the Eye

作者: T. Loftsson , E. Stefánsson

DOI: 10.3109/03639049709148496

关键词: ChemistryChromatographyTopical drugCyclodextrinIrritationDosage formDrugInclusion compoundAqueous solutionEye drop

摘要: … Cyclodextrins are oligosaccharides which form a new group of pharmaceutical excipients. Cyclodextrins have been added to aqueous eye drop preparations to solubilize lipophilic …

参考文章(34)
Kobayashi C, Takano T, Alba Rm, Kanai A, [The immunosuppressive effects of 0.025% cyclosporin eye drops in alpha cyclodextrin on rabbit corneal allografts]. Japanese Journal of Ophthalmology. ,vol. 96, pp. 834- ,(1992)
C. Trinadha Rao, Henry M. Fales, Josef Pitha, Pharmaceutical usefulness of hydroxypropylcyclodextrins: "e pluribus unum" is an essential feature. Pharmaceutical Research. ,vol. 7, pp. 612- 615 ,(1990) , 10.1023/A:1015818211518
Borgers M, Jansen T, Xhonneux B, Mesens J, Beta-cyclodextrins as vehicles in eye-drop formulations: an evaluation of their effects on rabbit corneal epithelium. Lens and eye toxicity research. ,vol. 7, pp. 459- ,(1990)
H Fridriksdóttir, S Thórisdóttir, J K Kristinsson, E Stefánsson, A M Sigurdardóttir, T Loftsson, Dexamethasone-cyclodextrin-polymer co-complexes in aqueous eye drops. Aqueous humor pharmacokinetics in humans. Investigative Ophthalmology & Visual Science. ,vol. 37, pp. 1199- 1203 ,(1996)
Pekka Jarho, Arto Urtti, Tomi Järvinen, Hydroxypropyl-beta-cyclodextrin increases the aqueous solubility and stability of pilocarpine prodrugs. Pharmaceutical Research. ,vol. 12, pp. 1371- 1375 ,(1995) , 10.1023/A:1016290127371
Arunya Usayapant, Adel H. Karara, Milind M. Narurkar, Effect of 2-hydroxypropyl-beta-cyclodextrin on the ocular absorption of dexamethasone and dexamethasone acetate. Pharmaceutical Research. ,vol. 8, pp. 1495- 1499 ,(1991) , 10.1023/A:1015838215268
Karl-Heinz Frömming, József Szejtli, Cyclodextrins in Pharmacy ,(1993)
Peter Vaupel, Ernst Mutschler, Gerhard Thews, Human anatomy, physiology, and pathophysiology Published in <b>1985</b> in Amsterdam by Elsevier. ,(1985)