[The immunosuppressive effects of 0.025% cyclosporin eye drops in alpha cyclodextrin on rabbit corneal allografts].

摘要: We reported the ocular penetration of cyclosporin (CYA) and immunosuppressive effect rabbit corneal allograft using 0.025% CYA eye drops in alpha-cyclodextrin (alpha-CD). Local application alpha-CD showed concentration 4,133 ng/gr cornea, but no detectable levels aqueous humor serum. All eyes (10/10) drop group remained clear for 100 days after allografting. halted suppressed allograft's immune reaction when treatment was begun early initial phase rejection. These results indicate that penetrate cornea 5 to 10 times more than lipophilic vehicles. Furthermore, they are extremely effective suppressing grafts.