Antigen-dependent alterations in the lipid composition of the CNS in guinea pigs with experimental allergic encephalomyelitis.
作者： B. Maggio , F.A. Cumar
DOI: 10.1016/0006-8993(74)90792-6
关键词: Biochemistry 、 Spinal cord 、 Antigen 、 Encephalomyelitis 、 Chemistry 、 Lipid composition 、 Endocrinology 、 Internal medicine 、 Experimental allergic 、 Myelin 、 Myelin basic protein 、 Cerebroside
摘要: Abstract The lipid content in brain and spinal cord was investigated guinea pigs with experimental allergic encephalomyelitis (EAE) induced whole rat cord, purified encephalitogenic protein or mixed CNS lipids. results indicated an independent alteration the of some myelin components depending on composition injection mixture. Changes cerebroside levels were found only animals sensitized basic contents sulfatides to be decreased a different degree which preparation used. more complex mixture injected, altered sulfatide content.
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sci-hub.se 参考文章(27)
F A Cumar, H S Barra, H J Maccioni, R Caputto, Sulfation of glycosphingolipids and related carbohydrates by brain preparations from young rats. Journal of Biological Chemistry. ,vol. 243, pp. 3807- 3816 ,(1968) , 10.1016/S0021-9258(18)92016-8
T. A. McPherson, G. S. M. Robson, I. R. Mackay, A histological dose-response effect in guinea-pigs injected with graded amounts of basic protein and peptides from human brain. British journal of experimental pathology. ,vol. 52, pp. 338- 344 ,(1971)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
RMC Dawson, J Eichberg, Diphosphoinositide and triphosphoinositide in animal tissues. Extraction, estimation and changes post mortem. Biochemical Journal. ,vol. 96, pp. 634- 643 ,(1965) , 10.1042/BJ0960634
RMC DAWSON, ON THE MECHANISM OF ACTION OF PHOSPHOLIPASE A. Biochemical Journal. ,vol. 88, pp. 414- 423 ,(1963) , 10.1042/BJ0880414
B. Maggio, F. A. Cumar, H. J. Maccioni, LIPID CONTENT IN BRAIN AND SPINAL CORD DURING EXPERIMENTAL ALLERGIC ENCEPHALO-MYELITIS IN RATS Journal of Neurochemistry. ,vol. 19, pp. 1031- 1037 ,(1972) , 10.1111/J.1471-4159.1972.TB01423.X
J. M. Fry, S. Weissbarth, G. M. Lehrer, M. B. Bornstein, Cerebroside Antibody Inhibits Sulfatide Synthesis and Myelination and Demyelinates in Cord Tissue Cultures Science. ,vol. 183, pp. 540- 542 ,(1974) , 10.1126/SCIENCE.183.4124.540
M. W. Kies, B. F. Driscoll, F. J. Seil, E. C. Alvord, Myelination Inhibition Factor: Dissociation from Induction of Experimental Allergic Encephalomyelitis Science. ,vol. 179, pp. 689- 690 ,(1973) , 10.1126/SCIENCE.179.4074.689
George I. Drummond, David Y. Eng, C. Anne McIntosh, Ribonucleoside 2′,3′-cyclic phosphate diesterase activity and cerebroside levels in vertebrate and invertebrate nerve Brain Research. ,vol. 28, pp. 153- 163 ,(1971) , 10.1016/0006-8993(71)90532-4
Russell E. Martenson, Gladys E. Deibler, Marian W. Kies, Myelin basic proteins of the rat central nervous system Purification, encephalitogenic properties, and amino acid compositions Biochimica et Biophysica Acta. ,vol. 200, pp. 353- 362 ,(1970) , 10.1016/0005-2795(70)90177-7