Protein-Induced Surface Structuring in Myelin Membrane Monolayers

摘要: Monolayers prepared from myelin conserve all the compositional complexity of natural membrane when spread at air-water interface. They show a complex pressure-dependent surface pattern that, on compression, changes coexistence two liquid phases to viscous fractal phase embedded in phase. We dissected role major protein components, basic (MBP), and Folch-Lees proteolipid (PLP) as crucial factors determining structural dynamics By analyzing mixtures single with lipids we found that MBP PLP have different behaviors. stabilizes segregation low pressures becomes excluded film under remaining adjacent PLP, contrary, organizes fractal-like included monolayer protein-free but it remains mixed MBP-induced The resultant topography is regulated by combined near equilibrium out-of-equilibrium effects. appears act skeleton for whole components whereas couples structuring extrusion adsorption processes.