18F‐sodium fluoride positron emission tomography of the equine distal limb: Exploratory study in three horses

摘要: Background Positron emission tomography (PET) is a cross-sectional, functional imaging modality that has recently become available to the horse. The use of 18 F-sodium fluoride (18 F-NaF), PET bone tracer, not previously been reported in this species. Objectives To assess feasibility F-NaF equine distal limb and explore possible applications horse comparison with other modalities. Study design Exploratory descriptive study involving three research horses. Methods Horses were placed under general anaesthesia prior intravenous (i.v.) administration 1.5 MBq/kg F-NaF. both front feet fetlocks was performed using portable scanner. Computed (CT) separate anaesthetic episode. Bone scintigraphy magnetic resonance (MRI) subsequently standing sedation. Images obtained from modalities independently assessed results correlated. Results images without complication. radiation exposure rate similar scintigraphy. detected focal uptake areas where did identify any abnormalities. This included sites ligamentous attachment, subchondral compact plate flexor cortex navicular bone. identified some, but all, osseous fragments formation, suggesting distinction between active inactive lesions. Main limitations A small number horses histopathology available. Conclusions provides useful additional information when compared CT, MRI potential for clinical Summary Chinese - see Supporting information.