A comparison of the metabolism of 25-hydroxyvitamine D3 by chick renal tubules, homegenates and mitochondria
作者： Daniel D. Bikle , Howard Rasmussen
DOI: 10.1016/0304-4165(74)90139-1
关键词: Internal medicine 、 Metabolism 、 Vitamin D and neurology 、 Endocrinology 、 Cytosol 、 Biology 、 Biochemistry 、 Mitochondrion 、 Calcium diet 、 Biophysics 、 Molecular biology
摘要: Abstract The metabolism of 25-hydroxycholecalciferol by chick renal tubules was compared to its homogenates and isolated mitochondria. preparation converted 1,25-hydroxycholecalciferol faster than the other preparations. Recombining mitochondria with cytosol markedly enhanced metabolism. Cytosol from kidneys vitamin D supplemented or 3.0% calcium diet animals worked as well that deficinet on 0.43% diet. cytocol did not change apparent K m mitochondrial 1α-hydroxylase. for in production calculated 3.2 · 10 −7 M.
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