Electrocardiogram Abnormalities Suggest Aberrant Cardiac Conduction in Huntington's Disease

摘要: Background There is increasing evidence that the effects of Huntington's disease (HD) extend beyond central nervous system. In particular, significant cardiac dysfunction has been described in transgenic mouse models and suggested symptomatic patients, whom involvement could provide an independent risk for sudden death. Methods Standard 12-lead electrocardiograms (ECGs) obtained at screening from 590 early (Stage 1 2) HD patients participating a multi-site Phase III study were analyzed. Results Evaluating only those ECGs individuals not on medications or with potentially contributing medical conditions, prevalence bradycardia was 28.3% (marked 5.8%), prolonged QRS 4.9%, intraventricular conduction delay 3.4%, right bundle branch block 1.3%, QTc prolongation 3.7%. Conclusion Significant abnormalities, characterized primarily by found larger than expected number patients. Abnormal may lead to increased arrhythmia be compounded prescription QT-prolonging medications.