Cardiac Dysautonomia in Huntington's Disease

摘要: Huntington's disease is a fatal, hereditary, neurodegenerative disorder best known for its clinical triad of progressive motor impairment, cognitive deficits and psychiatric disturbances. Although the central nervous system, mortality surveys indicate that heart leading cause death. The nature such cardiac abnormalities remains unknown. Clinical findings high prevalence autonomic system dysfunction - dysautonomia which may be result pathology network. Dysautonomia can have profound effects on health, pronounced associated with neurogenic arrhythmias sudden Significant advances in knowledge neural mechanisms recently been made further aid our understanding disease. Even so, despite evidence aberrant activity potential consequences somewhat ignored. In fact, underlying as part exclusion criteria research. A comprehensive analysis function patients warranted. Further experimental studies are needed to clarify how controlled regulated higher, areas brain these regions altered neurological pathology, Ultimately, research will hopefully an improvement management aim preventing early death from causes.