Neurocardiovascular pathology in pre‐manifest and early‐stage Huntington's disease

摘要: Background and purpose Cardiovascular events are a major cause of early death in the Huntington's disease (HD) population. Dysautonomia as well deterioration circadian rhythms can be detected progression have profound effects on cardiac health. The aim present study was to determine if patients with HD pre-manifest mutation carriers higher risk cardiovascular than non-mutation-carrying controls. Methods This prospective, cross-sectional, multicentre 38 (23 15 early-stage patients) compared age- gender-matched healthy Clinical epidemiological variables, including main haematological vascular factors, were recorded. Ambulatory blood-pressure monitoring carotid intima-media thickness (CIMT) measurement performed assess autonomic function target-organ damage markers. Results Most (63.2%) (86.7% 47.8%, respectively, non-dippers 23.7% controls (P = 0.001). CIMT values 75th percentile 46.7% 43.5%, patients, whereas none presented pathological 0.001 P 0.006, respectively). Nocturnal non-dipping significantly associated 0.002) but not Conclusions These results suggest that risks even patients. Although larger studies needed confirm these findings, clinicians should consider management HD.