Hypothalamic and Limbic System Changes in Huntington's Disease

摘要: Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Today, clinical diagnosis of requires unequivocal signs typical motor disturbances, which thought to be due pathology striatum basal ganglia. Increasing numbers studies have emphasized that also non-motor symptoms and are common occur early HD. These include psychiatric disturbances cognitive impairment as well sleep with disrupted circadian rhythm, autonomic dysfunction metabolic changes. Several features may results hypothalamus limbic system, interconnected structures central regulation emotion, metabolism. In fact, recent using postmortem tissue, magnetic resonance imaging positron emission tomography shown hypothalamic system changes This review summarizes current state knowledge this area based on experiments animal models establishes part HD pathology.