The neuronal and extraneuronal origins of plasma 3-methoxy-4-hydroxyphenylglycol in rats.
作者： Graeme Eisenhofer , Wendy Pecorella , Karel Pacak , Douglas Hooper , Irwin J. Kopin
DOI: 10.1016/0165-1838(94)90127-9
关键词: Catechol-O-methyl transferase 、 3-Methoxy-4-hydroxyphenylglycol 、 Metabolite 、 Endocrinology 、 Monoamine oxidase 、 Normetanephrine 、 Metabolism 、 Internal medicine 、 Norepinephrine (medication) 、 Chemistry 、 Catecholamine
摘要: 3-Methoxy-4-hydroxyphenylglycol (MHPG) is formed by the sequential actions of monoamine oxidase (MAO) and catechol-O-methyltransferase on norepinephrine within extraneuronal tissues or O-methylation 3,4-dihydroxyphenylglycol (DHPG) produced intraneuronally from norepinephrine. This study examined contributions neuronal metabolism to formation MHPG in rats. Spillover into plasma (605 +/- 28 pmol/kg per min) was higher than spillover DHPG (463 15 min), (165 9 normetanephrine (56 4 min). Comparison with increment after MAO inhibition (81 combined derived circulating (21 indicated that only 17% deamination norepinephrine; remaining 83% neurons. The production infused 30% entry bloodstream 53% (83-30) before its bloodstream. Metabolism made a minor (1-3%) contribution concentrations MHPG, but much larger (46%) normetanephrine. results provide comprehensive examination pathways. Since principal metabolite excreted rat, findings also show total body turnover dependent mainly transmitter; at rest pathways contribute as little 15% turnover.
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