Effect of Interval between Neoadjuvant Chemoradiotherapy and Surgery on Oncological Outcome for Rectal Cancer: A Systematic Review and Meta-Analysis
作者： Xiao-Jie Wang , Zheng-Rong Zheng , Pan Chi , Hui-Ming Lin , Xing-Rong Lu
DOI: 10.1155/2016/6756859
关键词: Colorectal cancer 、 Retrospective cohort study 、 Surgery 、 Cochrane Library 、 Neoadjuvant chemoradiotherapy 、 Abdominoperineal resection 、 Relative risk 、 Pathological 、 Medicine 、 Meta-analysis
摘要: Aim. To evaluate the influence of interval between neoadjuvant chemoradiotherapy (NCRT) and surgery on oncological outcome. Methods. A systematic search was conducted in PubMed, Cochrane Library, Embase databases for publications reporting outcomes patients following rectal cancer performed at different NCRT-surgery intervals. Relative risk (RR) pathological complete response (pCR) among intervals pooled. Results. Fifteen retrospective cohort studies representing 4431 met inclusion criteria. There a significantly increased rate pCR treated with followed 7 or 8 weeks later (RR, 1.45; 95% CI, 1.18-1.78; P < 0.01 RR, 1.49; 1.15-1.92; = 0.002, resp.). is no consistent evidence improved local control overall survival longer shorter Conclusion. Performing 7-8 after end NCRT results highest chance achieving pCR. For candidates abdominoperineal resection before NCRT, these data support implementation prolonging to optimize chances perhaps add possibility ultimate organ preservation.
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