Tumour regression in the randomized Stockholm III Trial of radiotherapy regimens for rectal cancer
作者： D. Pettersson , E. Lörinc , T. Holm , H. Iversen , B. Cedermark
DOI: 10.1002/BJS.9811
关键词:
摘要: Background The Stockholm III Trial randomized patients with primary operable rectal cancers to either short-course radiotherapy (RT) immediate surgery (SRT), RT delayed 4–8 weeks (SRT-delay) or long-course weeks. This preplanned interim analysis examined the pathological outcome of delaying surgery. Methods Patients SRT and SRT-delay arms in between October 1998 November 2010 were included, data collected a prospective register. Additional regarding tumour regression grade, according Dworak, circumferential margin obtained by reassessment histopathological slides. Results A total 462 545 had specimens available for reassessment. Patients earlier ypT categories, higher rate complete responses (11·8 versus 1·7 per cent; P = 0·001) Dworak grade 4 (10·1 P < 0·001) than without delay. Positive resection margins uncommon (6·3 cent) rates did not differ two treatment arms. Conclusion Short-course induces downstaging if is performed after an interval
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