Long non-coding RNA BLACAT1 promotes breast cancer cell proliferation and metastasis by miR-150-5p/CCR2
作者： Xiaopeng Hu , Yun Liu , Yaying Du , Teng Cheng , Wenfei Xia
DOI: 10.1186/S13578-019-0274-2
关键词: miR-150 、 Breast cancer 、 Metastasis 、 Long non-coding RNA 、 Stem cell 、 Cancer research 、 Proteomics 、 CCR2 、 Cancer cell 、 Medicine
摘要: Breast cancer was dangerous to women health. A growing number of evidences indicate that long non-coding RNAs (lncRNAs) have many functions in the development and progression breast may serve as markers diagnosis or prognosis. BLACAT1 is one lncRNA roles it not clear. In this study, aimed explore molecular mechanisms cancer. We found took part cell aggressive phenotype. The real-time PCR result showed up-regulated tumor tissues compared adjacent normal tissues. mechanism experiments demonstrated down-regulation suppressed proliferation metastasis human cells by regulating miR-150-5p targeting CCR2. clinical studies indicated lack related size, metastasis. Conclusion: present study verified involvement mediation survival through CCR2 cells.
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