Long Noncoding RNA Bladder Cancer Associated Transcript 1 Promotes the Proliferation, Migration, and Invasion of Nonsmall Cell Lung Cancer Through Sponging miR-144.

摘要: Nonsmall cell lung cancer (NSCLC) is a type of malignant tumor, accounting for 80% all morbidity. Long noncoding RNA (lncRNA) BLACAT1 (bladder associated transcript 1), also known as linc-UBC1, has been tested to be an oncogenic lncRNA in other cancers. However, the role NSCLC still unknown. In clinical study, expression was significantly upregulated 48 cases tissues compared with adjacent normal tissues, especially pathological TNM III samples. cells, upregulated. Both vivo and vitro, silencing transfected si-BLACAT1 could suppress proliferation, migration, invasion, induce G0/G1 phase arrest. Bioinformatics methods luciferase reporter assay revealed close link within miR-144 3'-untranslated region (UTR). Furthermore, combining experiments indicated that reverse function on cells' phenotype. Overall, this study reveals overexpression tissue discovers genesis through sponging miR-144, providing potential biomarker early detection prognosis prediction NSCLC.