Long noncoding RNA linc-UBC1 is negative prognostic factor and exhibits tumor pro-oncogenic activity in gastric cancer.

摘要: Despite the advances in management of gastric cancer, prognosis advanced cancer remains relatively poor. Thus, it is urgent need to identify novel prognostic markers and therapeutic targets cancer. A growing volume literature has indicated that lncRNAs are differentially expressed a diverse array play an important role development Linc-UBC1, recently identified long noncoding RNA, was initially found be upregulated bladder However, linc-UBC1 elusive. In this study, we significantly tissues compared adjacent normal tissues. Furthermore, high expression associated with lymph-node metastasis, tumor size, TNM stage poorer prognosis. Inhibition suppressed proliferation, motility invasion cells. Our study suggests may represent diagnostic, biomarker potential target