The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins

摘要: Insulin-like peptides, such as insulin-like growth factors (IGFs) and insulin, induce a variety of bioactivities, growth, differentiation, survival, increased anabolism, decreased catabolism in many cell types vivo. In general, IGFs or insulin bind to IGF-I receptor (IGF-IR) (IR), activating the tyrosine kinase. Insulin substrates (IRSs) are known be major kinases, mediating IGF/insulin signals direct bioactivities. Recently, we discovered that IRSs form high-molecular-mass complexes (referred here IRSomes) even without stimulation. These contain proteins IRSAPs; IRS-associated proteins), which modulate phosphorylation by control IRS stability, determine intracellular localization IRSs. addition, these complexes, found not only involved RNA metabolism but also RNAs themselves. Thus, IRSAPs possibly contribute modulation Since it is established disorder activities causes various age-related diseases including cancer, could propose IRSome an important target for treatment diseases.