Diagnosing and Grading Gliomas Using a Proteomics Approach

作者: Richard Caprioli

DOI:

关键词: Protein expressionGliomaComputational biologyProteomicsBioinformaticsPatient survivalGrading (tumors)Biology

摘要: The present invention provides for a proteomic approach to grading gliomas, and predicting patient survival. In addition employing global protein expression patterns, such as by mass spectrometry, particular target proteins whose is altered in various gliomas can be used predict the stage/classificiation of glioma, well indicate whether given will short- or long-term survivor.

参考文章(28)
Marti Jett-Tilton, Rina Das, Roger Neill, Diagnosis of stage or aggressiveness of cancer ,(1999)
Roland Pochet, Christine Decaestecker, Claus W Heizmann, Yves Bronckart, Isabelle Salmon, Robert Kiss, Nathalie Nagy, Luke H. Harper, Beat W. Schäfer, Development and progression of malignancy in human colon tissues are correlated with expression of specific ca2+-binding S100 proteins Histology and Histopathology. ,vol. 16, pp. 707- 712 ,(2001) , 10.14670/HH-16.707
Todd R. Golub, Scott Pomeroy, Pablo Tamayo, Eric S. Lander, Brain tumor diagnosis and outcome prediction ,(2002)
Pierre Chaurand, Melinda E. Sanders, Roy A. Jensen, Richard M. Caprioli, Proteomics in Diagnostic Pathology : Profiling and Imaging Proteins Directly in Tissue Sections American Journal of Pathology. ,vol. 165, pp. 1057- 1068 ,(2004) , 10.1016/S0002-9440(10)63367-6
Wa'el El-Rifai, Christopher A. Moskaluk, Cynthia Yoshida, Henry F. Frierson, Gregory J. Riggins, Steven M. Powell, Jeffery Harper, Mohammad Khalouck Abdrabbo, Gastric Cancers Overexpress S100A Calcium-binding Proteins Cancer Research. ,vol. 62, pp. 6823- 6826 ,(2002)
Markus Stoeckli, Pierre Chaurand, Dennis E. Hallahan, Richard M. Caprioli, Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues. Nature Medicine. ,vol. 7, pp. 493- 496 ,(2001) , 10.1038/86573
M. Bittner, P. Meltzer, Y. Chen, Y. Jiang, E. Seftor, M. Hendrix, M. Radmacher, R. Simon, Z. Yakhini, A. Ben-Dor, N. Sampas, E. Dougherty, E. Wang, F. Marincola, C. Gooden, J. Lueders, A. Glatfelter, P. Pollock, J. Carpten, E. Gillanders, D. Leja, K. Dietrich, C. Beaudry, M. Berens, D. Alberts, V. Sondak, N. Hayward, J. Trent, Molecular classification of cutaneous malignant melanoma by gene expression profiling Nature. ,vol. 406, pp. 536- 540 ,(2000) , 10.1038/35020115
Gerolama Condorelli, Giovanni Vigliotta, Carlo Iavarone, Matilde Caruso, Carlo Gabriele Tocchetti, Francesco Andreozzi, Almerinda Cafieri, Mario F. Tecce, Pietro Formisano, Laura Beguinot, Francesco Beguinot, PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus The EMBO Journal. ,vol. 17, pp. 3858- 3866 ,(1998) , 10.1093/EMBOJ/17.14.3858
Libo Zhang, Darin K. Fogg, David M. Waisman, RNA interference-mediated silencing of the S100A10 gene attenuates plasmin generation and invasiveness of Colo 222 colorectal cancer cells Journal of Biological Chemistry. ,vol. 279, pp. 2053- 2062 ,(2004) , 10.1074/JBC.M310357200