Differences in brain structure and function in older adults with self-reported disabling and nondisabling chronic low back pain.

摘要: Objective.  The primary aim of this pilot study was to identify structural and functional brain differences in older adults with self-reported disabling chronic low back pain (CLBP) compared those who reported nondisabling CLBP. Design.  Cross-sectional. Participants.  Sixteen cognitively intact adults, eight CLBP CLBP. Exclusions were psychiatric or neurological disorders, substance abuse, opioid use, diabetes mellitus. Methods.  Participants underwent: MRI; neuropsychological assessment using the Repeatable Battery for Assessment Neuropsychological Status, Trail Making Tests A B; physical performance Short Physical Performance Battery. Results.  In disabled group, there significantly lower white matter (WM) integrity (P < 0.05) splenium corpus callosum. This group also demonstrated activation right medial prefrontal cortex at rest whereas nondisabled left lateral cortex. Combined groups analysis revealed a strong positive correlation (rs = 0.80, P < 0.0002) between WM centrum semiovale gait-speed. Secondary negative total months SCC (rs = −0.59, P < 0.02). Conclusions.  Brain structure function is different Deficits morphology combining are associated duration poor function. Our findings suggest may play key role related disability be important treatment targets.