Reduction of brain injury using heparin to inhibit leukocyte accumulation in a rat model of transient focal cerebral ischemia. II. Dose-response effect and the therapeutic window.

摘要: The administration of massive doses heparin has been demonstrated to reduce reperfusion injury. authors have found that heparin's antileukocyte adhesion property may play a more important role than its anticoagulant in preventing ischemia and Although the brain injury after reperfusion, optimum dosage timing for remain unknown. purpose this study was evaluate dose-response effect determine time during which must be administered inhibit leukocyte accumulation, infarct size, improve neurological outcome rats subjected 1 hour cerebral 48 hours reperfusion. Forty-nine animals were included study. receiving commercial unfractionated at total dose 2.67 4 mg/kg showed significant inhibition reduced lessened dysfunction (p < 0.05) when compared untreated animals. within 3 also significantly better results These data indicate standard prevent injury, relatively late postischemic is effective protection. findings therapeutic potential as an adjunct thrombolytic therapy possibly other perfusion deficiencies with leukocyte-endothelial interaction. In view these encouraging experimental findings, clinical application warrants serious consideration.