Physiologic and cortical response to acute psychosocial stress in left temporal lobe epilepsy — A pilot cross-sectional fMRI study

摘要: Abstract Stress is commonly reported as a seizure precipitant in individuals with poorly controlled seizures including temporal lobe epilepsy. The aim of the study was to assess neural and physiologic correlates psychosocial stress response during functional magnetic resonance imaging (fMRI) their relationship occurrence patients left epilepsy (LTLE). We enrolled 23 LTLE age- sex-matched healthy controls (HCs); all underwent fMRI control math task (CMT) (SMT) pre-/post-fMRI salivary cortisol analysis (acute reactivity calculated % reduction from post-stress recovery baseline; dCORT). Beck Depression Inventory-II (BDI-II) Perceived Scale (PSS-10) were administered. T-tests performance variables performed. Processing single-subject modeling CMT positive feedback SMT negative feedback, group comparisons, whole-brain correlation Patients similar demographics, performance, heart rate, PSS-10 scores (all p > 0.05). exhibited greater dCORT (p = 0.048) lower BDI-II (p = 0.016) compared HCs. showed association between frequency (r = 0.73, p = 0.016). Functional MRI activation groups, midfrontal, temporal, parietal, occipital regions. Regression analyses revealed no differences but, HCs, decreased cerebellum/middle occipital/fusiform gyri, hippocampus/parahippocampus, bilateral medial frontal/cingulate/superior frontal right postcentral gyrus/inferior parietal lobule, insula/postcentral gyrus (p