Gestational trophoblastic neoplasia after achieving a nondetectable serum human chorionic gonadotrophin level.

摘要: Objective To determine the risk of recurrent trophoblastic disease after normalisation human chorionic gonadotrophin (hCG) levels in women with hydatidiform mole. Design A retrospective review data from a national gestational centre. Setting The Trophoblastic Disease Unit, Dakar, Senegal. Sample Women pregnancies affected by mole registered between 2006 and 2012. Methods The were followed up accordance hospital protocol ‘Score de Dakar’. For who progressed to neoplasia (GTN) time onset GTN, treatment evolution evaluated. The rate GTN hCG was determined. Main outcome measures Rate occurrence chemotherapy for mole. Results Five hundred thirty-one diagnosed have molar pregnancies. According hospital's protocol, 107 (20.2%) these had 224 (42.2%) prophylactic chemotherapy. Five thirteen (96.4%; 95% confidence interval [95% CI] 95.05–98.14%) achieved remission. Eighteen (3.4%; CI 1.86–4.94%) developed (11 before remission seven remission). Seven out 18 (1.3%). beyond recommended period follow up. mean diagnosis 18.7 months. These underwent combination chemotherapy: five complete whereas two died GTN. Conclusions Cytotoxic therapy does not prevent it delays its promotes hCG.