Drastic decline of hepatitis E virus detection in domestic pigs after the age of 6 months, Corsica, France.

摘要: Suidae is an important reservoir of hepatitis E virus (HEV) and a source transmission to humans (direct contact or via consumption meat products). Our goal was characterize the epidemiology HEV infecting domestic pigs in Corsica Island, French region hyperendemic for HEV. In Corsica, traditional extensive (or semi-extensive) outdoor pig farming system common. Sixteen farms were selected according location breeding system. Individual faeces samples collected qRT-PCR detecting RNA performed. Nucleic acids from HEV-positive amplified using specific ORF2 genotyping The genotype subtype Corsican sequences determined by phylogenetic analysis. Among 919 porcine tested 9.2% (n = 85) positive. presence viral correlated with (a) age (>6 months) Adjusted Odd Ratio (AOR) 0.25 [0.068-0.90] p = .032; 3-4 months AOR = 4.94 [2.30-10.62] p = .000043) logistic regression model random effect at farm level. 85 positive samples, 83 belonged 3c two 3f. highest prevalence observed group older negatively related infection this suggests that late slaughter may limit risk humans. A kinetic study birth slaughtering would allow ensure type reported here very favourable absence slaughtered pork products.