Origin, evolution, and migration of drug resistance genes
作者： S. Z. Mindlin , M. A. Petrova , I. A. Bass , Zh. M. Gorlenko
DOI: 10.1134/S1022795406110081
关键词: Plasmid 、 Mobile genetic elements 、 Biology 、 Bacteria 、 Microbiology 、 Transposable element 、 Gene 、 Horizontal gene transfer 、 Genetics 、 Drug resistance 、 Multiple drug resistance
摘要: Current views on the mechanisms responsible for emergence of multiple drug resistance in clinical bacterial isolates are considered. Hypotheses origin genes derived from determinants actinomycetes, antibiotic-producing strains, and chromosomal bacteria involved cellular metabolism reviewed. The underlying diffusion by means mobile elements (plasmids, transposons, integrons) discussed. Examples horizontal transfer between Gram-positive Gram-negative presented.
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