Gentamicin production by Micromonospora echinospora (Me- 22) in stirred tank reactor: effect of various parameters.
作者： Himabindu Meenavilli , Ravichandra Potumarthi , Annapurna Jetty
关键词: Starch 、 Lab scale 、 Volume concentration 、 Continuous stirred-tank reactor 、 Aeration rate 、 Aeration 、 Chemical engineering 、 Chemistry 、 Micromonospora echinospora 、 Gentamicin 、 Food science
摘要: Effect of production medium components, initial starch and soyabean meal concentrations, for the enhanced gentamicin by Micromonospora echinospora (Me- 22) was studied in a lab scale stirred tank reactor. Also effect different aeration (0.5, 1, 2, 4 vvm) agitation rates (100, 200, 300 400 rpm) reactor examined. A maximum concentration 2.68 g l–1 achieved having low concentrations (7.5 l–1) high (4 l–1). Both significantly affected concentration, productivity biomass formation. The 4.12 highest yield on substrate 0.967 g–1 were obtained at impeller speed 200 rpm rate 2 vvm. Under optimal culture conditions STR could be increased 3 fold when compared with shake flask. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
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