Enhancement of gentamicin production by mutagenesis and non-nutritional stress conditions in Micromonospora echinospora
作者： M. Himabindu , Ravichandra Potumarthi , Annapurna Jetty
DOI: 10.1016/J.PROCBIO.2007.05.002
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摘要: Abstract Gentamicin producing strain of Micromonospora echinospora was treated with chemical mutagens like EtBr and MNNG physical such as UV carried out to obtain a mutant enhanced production gentamicin. After inducing mutations screening for penicillin kanamicin resistant mutants done. M. EtBr-22 obtained by its gentamicin in shake flask reaches 1354 mg l −1 which is 1.53-fold higher than that the parent strain. Application different stress conditions heat shock, feeding high ethanol NaCl concentrations during fermentation has found be effective increased Production 1.26-fold medium supplemented 0.6% 48-h-old culture.
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