DXA in the assessment of subchondral bone mineral density in knee osteoarthritis--A semi-standardized protocol after systematic review.

摘要: Abstract Introduction Subchondral bone mineral density (sBMD) contributes to the initiation and progression of knee osteoarthritis (OA). Reliable methods assess sBMD status may predict response specific OA phenotypes targeted therapies. While dual-energy X-ray absorptiometry (DXA) can determine sBMD, no consensus exists regarding its methodology. Objective Construct a semi-standardized protocol for DXA measure in patients with by evaluating varying methodologies present existing literature. Methods We performed systematic review original papers published PubMed Web Science from their inception July 2014 using following search terms: subchondral bone, osteoarthritis, density. Results be similar reproducibility values those proposed International Society Clinical Densitometry hip spine. identified acquisition view, rotation, positioning stabilization, ROI location definition, type analysis software as important sources variation. A was constructed taking into consideration results review. Conclusions reliably OA. Nevertheless, we found substantial methodological variation across previous studies. Methodological standardization provide foundation which establish valid tool identification SB changes an outcome clinical trials disease modifying osteoarthritic drugs.