A combined oral contraceptive affects mucosal SHIV susceptibility factors in a pigtail macaque (Macaca nemestrina) model.

作者: Sharon Dietz Ostergaard , Katherine Butler , Jana M. Ritter , Ryan Johnson , Jeanine Sanders

DOI: 10.1111/JMP.12157

关键词: Biological risk factorsHormonal contraceptionImmunologyBiologyVaginaMacaca nemestrinaPigtail macaqueSimian immunodeficiency virusLevonorgestrelMenstrual cycle

摘要: Background Injectable hormonal contraception may increase women’s risk of HIV acquisition, and can affect biological factors in animal models HIV. We established, for the first time, a model to investigate whether combined oral contraceptives (COC) alter SHIV susceptibility macaques.

参考文章(39)
Lauren Harris-Kojetin, Roberto Valverde, Adrienne L Jones, Characteristics and use of home health care by men and women aged 65 and over. National health statistics reports. ,vol. 2012, pp. 1- 7 ,(2012)
S. K. Srivastava, V. P. Kamboj, G. P. Dutta, K. K. Kamboj, S. K. Puri, Interactions between oral contraceptives and malaria infections in rhesus monkeys. Bulletin of The World Health Organization. ,vol. 62, pp. 931- 939 ,(1984)
A. Gettie, Chris J Miller, P. A. Marx, D. L. Sodora, Vaginal transmission of SIV: assessing infectivity and hormonal influences in macaques inoculated with cell-free and cell-associated viral stocks. AIDS Research and Human Retroviruses. ,vol. 14, ,(1998)
Lindsay Livingston, Elizabeth Sweeney, James Mitchell, Wei Luo, Katherine Paul, Nathaniel Powell, R. Michael Hendry, Janet McNicholl, Ellen Kersh, Hormonal synchronization of the menstrual cycles of pigtail macaques to facilitate biomedical research including modeling HIV susceptibility. Journal of Medical Primatology. ,vol. 40, pp. 164- 170 ,(2011) , 10.1111/J.1600-0684.2010.00465.X
Neelima Chandra, Andrea Ries Thurman, Sharon Anderson, Tina Duong Cunningham, Nazita Yousefieh, Christine Mauck, Gustavo F. Doncel, Depot medroxyprogesterone acetate increases immune cell numbers and activation markers in human vaginal mucosal tissues. AIDS Research and Human Retroviruses. ,vol. 29, pp. 592- 601 ,(2013) , 10.1089/AID.2012.0271
Preston A. Marx, Alexander I. Spira, Agegnehu Gettie, Peter J. Dailey, Ronald S. Veazey, Andrew A. Lackner, C. James Mahoney, Christopher J. Miller, Lee E. Claypool, David D. Ho, Nancy J. Alexander, Progesterone implants enhance SIV vaginal transmission and early virus load Nature Medicine. ,vol. 2, pp. 1084- 1089 ,(1996) , 10.1038/NM1096-1084
Toni M Dando, Monique P Curran, Low-Dose Ethinylestradiol/Levonorgestrel Drugs. ,vol. 65, pp. 2299- 2306 ,(2005) , 10.2165/00003495-200565160-00007
Deborah J. Anderson, Jai Marathe, Jeffrey Pudney, The structure of the human vaginal stratum corneum and its role in immune defense. American Journal of Reproductive Immunology. ,vol. 71, pp. 618- 623 ,(2014) , 10.1111/AJI.12230