The motor effects of bromocriptine--a review.

摘要: For many years, bromocriptine has proven to be a useful treatment for some of the disabling motor effects seen in Parkinson's disease. As such, it been only commonly used directly acting D2 agonist available. But its mechanism action obscure because animal models indicated an absolute requirement presence endogenous DA have any efficacy, despite undoubted occupation receptor with high affinity. Several scattered reports indicated, however, that could potentiate number other dopamine agonists (such as apomorphine and l-dopa) variety pharmacological clinic. With availability SKF38393 SCH23390, soon became clear bromocriptine, while selective agonist, depended sense on integrity D1 receptors. Thus, if was administered together rodents depleted dopamine, marked locomotor excitation produced, either drug alone being inactive. The present review explores literature endeavours integrate behavioural, biochemical electrophysiological into coherent whole. It closes consideration several remaining unsolved problems associated pharmacology suggests future studies.