Susceptibility to onion-induced hemolysis in dogs with hereditary high erythrocyte reduced glutathione and potassium concentrations.

摘要: The hemolytic effect of onion consumption in dogs with hereditary high erythrocyte reduced glutathione and potassium concentrations (designated HK dogs) was compared that clinically normal dogs. Twelve hours after oral administration boiled onions (200 g/dog), hemoglobin concentration decreased to 84.4% the initial value dogs; it only 90.5% At 24 hours, methemoglobin significantly (P less than 0.05) higher oxidized increased about fivefold at 10 dogs, whereas did not change during experimental period In addition, 12 proportion erythrocytes containing Heinz bodies 24.4% but 1.2% Thus, results indicated were more susceptible oxidant action