DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer.

作者: Joaquin Mateo , Suzanne Carreira , Shahneen Sandhu , Susana Miranda , Helen Mossop

DOI: 10.1056/NEJMOA1506859

关键词: ProstateProstate cancerPoly (ADP-Ribose) Polymerase InhibitorPathologyMedicineRucaparibResponse Evaluation Criteria in Solid TumorsCancer researchOlaparibCancer biomarkersCancer

摘要: … , and the PARP inhibitor olaparib (Lynparza, AstraZeneca) … We hypothesized that olaparib would have antitumor activity … -resistant prostate cancer with olaparib, obtaining fresh tumor-…

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