Odontogenic keratocyst expresses vascular endothelial growth factor: an immunohistochemical study

摘要: Department of Histology andEmbryology, Medical School, National and Kapodestrian University Athens, GreeceBACKGROUND: Vascular endothelial growth factor(VEGF) expression may act as a sensitive measure theangiogenic potential lesion. Furthermore, VEGF hasbeen implicated in the pathogenesis cystic tumors andinflammatory odontogenic cysts. Thus, we studied theexpression epithelium odontogenickeratocyst (OK) association with cell proliferation andapoptosis.METHODS: Forty-two cases OK, 26 denti-gerous cyst (DC), 15 residual (RC)were retrospectively examined by immunohistochem-istry for VEGF, Ki67⁄Mib-1 anti-caspase-3. ForVEGF caspase-3, intensity immunostainingwas qualitatively assessed, while evaluationof Ki67 average number positively stained nucleiin 10 high-power microscopic fields ( ·400) was calcu-lated.RESULTS: The stronger OKwhen compared DC P < 0.007). rate nuclearKi67 OK significantly higher than thatin (P 0.001) RC 0.001). Cytoplasmic cas-pase-3 statistically more intense RCthan = or A statisticallysignificant correlation seen 0.001)and 0.023), but not caspase-3. Multipleregression analysis revealed linear relationship betweenVEGF Ki67.CONCLUSIONS: expressed epi-thelium DC, variable intensity, andin related to Ki67. It issuggested that odontogenicepithelium is induced solely inflammation.J Oral Pathol Med (2009) 38: 470–475Keywords: caspases; dentigerous cyst; Ki67; kera-tocyst;