Cholesterol Trafficking in CaCo-2 Cells
作者： F. Jeffrey Field
DOI: 10.1007/978-1-4615-5113-3_9
关键词: Golgi apparatus 、 Caveolae 、 Cholesterol 、 Caveolin 、 Secretion 、 Vesicle 、 Endoplasmic reticulum 、 Cell biology 、 Chemistry 、 Membrane
摘要: In CaCo-2 cells, the transport of cholesterol from plasma membrane to endoplasmic reticulum occurs via vesicles, likely derived specialized domains membrane. Agents that inhibit p-glycoprotein activity interfere with and secretion triacylglycerol-rich lipoproteins. The uptake micellar causes “clustering” microdomains containing caveolin. It is it these areas fluxes reticulum. Cholesterol major substrate for ACAT lipoprotein cholesterol. newly-synthesized constitutive independent Golgi, microtubular function, new protein synthesis, or p-glycoprotein. cells regulate amount arriving at by altering rate not process. pathways are distinct.
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