The insulin signaling system.

作者: M.F. White , C.R. Kahn

DOI: 10.1016/S0021-9258(17)42297-6

关键词: Insulin Receptor Substrate ProteinsInsulin receptorEndocrinologyReceptorBiologyInsulin metabolismSignal transductionInsulinKinaseInternal medicinePeptide hormone

摘要:

参考文章(68)
R. Yamamoto-Honda, T. Kadowaki, K. Momomura, K. Tobe, Y. Tamori, Y. Shibasaki, Y. Mori, Y. Kaburagi, O. Koshio, Y. Akanuma, Normal insulin receptor substrate-1 phosphorylation in autophosphorylation-defective truncated insulin receptor : evidence that phosphorylation of substrates might be sufficient for certain biological effects evoked by insulin Journal of Biological Chemistry. ,vol. 268, pp. 16859- 16865 ,(1993) , 10.1016/S0021-9258(19)85495-9
N Longo, R.C. Shuster, L.D. Griffin, S.D. Langley, L.J. Elsas, Activation of insulin receptor signaling by a single amino acid substitution in the transmembrane domain. Journal of Biological Chemistry. ,vol. 267, pp. 12416- 12419 ,(1992) , 10.1016/S0021-9258(18)42290-9
AS Andersen, T Kjeldsen, FC Wiberg, H Vissing, L Schäffer, JS Rasmussen, P De Meyts, NP Møller, None, Identification of determinants that confer ligand specificity on the insulin receptor. Journal of Biological Chemistry. ,vol. 267, pp. 13681- 13686 ,(1992) , 10.1016/S0021-9258(18)42267-3
S.B. Waters, K Yamauchi, J.E. Pessin, Functional expression of insulin receptor substrate-1 is required for insulin-stimulated mitogenic signaling. Journal of Biological Chemistry. ,vol. 268, pp. 22231- 22234 ,(1993) , 10.1016/S0021-9258(18)41513-X
J.M. Backer, C.R. Kahn, M.F. White, The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells. Journal of Biological Chemistry. ,vol. 265, pp. 14828- 14835 ,(1990) , 10.1016/S0021-9258(18)77189-5
E.P. Feener, J.M. Backer, G.L. King, P.A. Wilden, X.J. Sun, C.R. Kahn, M.F. White, Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor. Journal of Biological Chemistry. ,vol. 268, pp. 11256- 11264 ,(1993) , 10.1016/S0021-9258(18)82118-4
Y. Kaburagi, K. Momomura, R. Yamamoto-Honda, K. Tobe, Y. Tamori, H. Sakura, Y. Akanuma, Y. Yazaki, T. Kadowaki, Site-directed mutagenesis of the juxtamembrane domain of the human insulin receptor. Journal of Biological Chemistry. ,vol. 268, pp. 16610- 16622 ,(1993) , 10.1016/S0021-9258(19)85463-7
A.L. Frattali, J.L. Treadway, J.E. Pessin, Evidence supporting a passive role for the insulin receptor transmembrane domain in insulin-dependent signal transduction Journal of Biological Chemistry. ,vol. 266, pp. 9829- 9834 ,(1991) , 10.1016/S0021-9258(18)92894-2
P.A. Wilden, C.R. Kahn, K Siddle, M.F. White, Insulin receptor kinase domain autophosphorylation regulates receptor enzymatic function. Journal of Biological Chemistry. ,vol. 267, pp. 16660- 16668 ,(1992) , 10.1016/S0021-9258(18)42053-4
X.J. Sun, M Miralpeix, M G Myers, E.M. Glasheen, J.M. Backer, C.R. Kahn, M.F. White, Expression and function of IRS-1 in insulin signal transmission. Journal of Biological Chemistry. ,vol. 267, pp. 22662- 22672 ,(1992) , 10.1016/S0021-9258(18)41723-1