Insulin-Like Growth Factor-1 Receptor as a Target for Anticancer Therapy
作者： Renato Baserga , Mariana Resnicoff
DOI: 10.1007/978-1-59259-720-8_13
关键词: Biology 、 Cancer research 、 Cell growth 、 Downregulation and upregulation 、 Receptor 、 In vitro 、 Insulin-like growth factor 、 Apoptosis 、 Insulin receptor 、 In vivo
摘要: The type 1 receptor for the insulin-like growth factors (IGF-1R) plays a major role in control of cell proliferation, both vitro and vivo. Downregulation IGF-1R function by variety procedures causes large-scale apoptosis cells, especially when cells are anchorage-independent conditions. ability targeted to discriminate between contact-inhibited anchorage-independence has been exploited animals abrogate tumor growth.
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sci-hub.st 参考文章(49)
E.A. Harrington, M.R. Bennett, A. Fanidi, G.I. Evan, c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. The EMBO Journal. ,vol. 13, pp. 3286- 3295 ,(1994) , 10.1002/J.1460-2075.1994.TB06630.X
J.M. Backer, M.G. Myers, X.J. Sun, D.J. Chin, S.E. Shoelson, M. Miralpeix, M.F. White, Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells. Journal of Biological Chemistry. ,vol. 268, pp. 8204- 8212 ,(1993) , 10.1016/S0021-9258(18)53083-0
Renato Baserga, Mariana Resnicoff, Consuelo D'Ambrosio, Barbara Valentinis, The role of the IGF-I receptor in apoptosis. Vitamins and Hormones Series. ,vol. 53, pp. 65- 98 ,(1997) , 10.1016/S0083-6729(08)60704-9
Xiao Tu, Renato Baserga, Krzysztof Reiss, Consuelo D'Ambrosio, Chi Tu, Inhibition of tumor growth by a dominant negative mutant of the insulin-like growth factor I receptor with a bystander effect. Clinical Cancer Research. ,vol. 4, pp. 2647- 2655 ,(1998)
Matthew L. Albert, Birthe Sauter, Nina Bhardwaj, Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs Nature. ,vol. 392, pp. 86- 89 ,(1998) , 10.1038/32183
Mariana Resnicoff, Michele Rubini, Raphael Rubin, Christian Sell, Renato Baserga, Domenico Coppola, Diane Ambrose, Rat Glioblastoma Cells Expressing an Antisense RNA to the Insulin-like Growth Factor-1 (IGF-1) Receptor Are Nontumorigenic and Induce Regression of Wild-Type Tumors Cancer Research. ,vol. 54, pp. 2218- 2222 ,(1994)
M.F. White, C.R. Kahn, The insulin signaling system. Journal of Biological Chemistry. ,vol. 269, pp. 1- 4 ,(1994) , 10.1016/S0021-9258(17)42297-6
Mariana Resnicoff, Andres Ferber, Renato Baserga, Consuelo D'Ambrosio, A Soluble Insulin-like Growth Factor I Receptor That Induces Apoptosis of Tumor Cells in Vivo and Inhibits Tumorigenesis Cancer Research. ,vol. 56, pp. 4013- 4020 ,(1996)
P J Smith, L S Wise, R Berkowitz, C Wan, C S Rubin, Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes. Journal of Biological Chemistry. ,vol. 263, pp. 9402- 9408 ,(1988) , 10.1016/S0021-9258(19)76555-7
Raphael Rubin, Pnina Brodt, Renato Baserga, Li Long, Loss of the Metastatic Phenotype in Murine Carcinoma Cells Expressing an Antisense RNA to the Insulin-like Growth Factor Receptor Cancer Research. ,vol. 55, pp. 1006- 1009 ,(1995)