IGF-I Receptor Function
作者： Vicky A. Blakesley , Andrew A. Butler , Anatolii P. Koval , Yumiko Okubo , Derek LeRoith
DOI: 10.1007/978-1-59259-712-3_7
关键词:
摘要: The insulin-like growth factor (IGF)-I receptor, or type 1 IGF is a transmembrane tyrosine kinase receptor that mediates the majority of biological actions IGF-I and IGF-II (1,2). ligands, IGF-II, bind to extracellular domain initiate conformational change transmitted intracellular domain. then autophosphorylated on several residues. tyrosine-phosphorylated fully active as toward endogenous substrates. Both circulate bound binding proteins (IGFBPs) (3). IGF—IGFBP complexes either enhance inhibit action in tissue-specific manner known roles IGFBPs are presented other chapters. Whereas regulate activation by its cognate constitutes ultimate requisite for transduction IGF-mediated signals.
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