Heat shock proteins and immunity: Application of hyperthermia for immunomodulation
作者： Toshihiko Torigoe , Yasuaki Tamura , Noriyuki Sato
DOI: 10.3109/02656730903315831
关键词: Immunity 、 Antigen presentation 、 Biology 、 Acquired immune system 、 Immune system 、 Immunology 、 Heat shock protein 、 MHC class I 、 Antigen-presenting cell 、 Innate immune system
摘要: Heat shock proteins (HSPs) play an important role as 'endogenous danger signals' in the immune surveillance system. Extracellular HSPs released from damaged cells can stimulate professional antigen-presenting cells, followed by cytokine release and expression of cell surface molecules. In addition to such activity stimulating innate immunity, extracellular promote cross-presentation HSP-bound peptide antigens MHC class I molecules dendritic leading efficient induction antigen-specific cytotoxic T-lymphocytes. The roles both immunity adaptive explain at least part molecular mechanism which thermal stress bolsters host present review, we novel aspects discuss therapeutic application hyperthermia for immunomodulation.
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