Such stuff as dreams are made on: mediator-directed therapy in sepsis.

摘要: Sepsis, a life-threatening disorder that arises through the body's response to infection, is leading cause of death and disability for patients in an intensive care unit. Advances understanding complex biological processes responsible clinical syndrome have led identification many promising new therapeutic targets, including bacterial toxins, host-derived mediators, downstream such as coagulation endocrine response. Diverse therapies directed against these targets shown dramatic effects animal models; however, humans, their impact has been frustratingly modest, only one agent--recombinant activated protein C--has achieved regulatory approval. This review summarizes approaches evaluated trials, explores reasons discordance between promise reality, points may lead greater success future.