摘要: The term “genomics” has morphed into an umbrella to describe broadly the large-scale study of genes, gene products, variants, and their impact on health disease. This chapter reviews genomics critical illness injury. will also review other “omics” such as proteomics, pharmacogenomics, epigenetics, lipidomics, metabolomics. Gene association studies attempt link variants with susceptibility outcomes from various forms illness. Genome wide expression have been leveraged elucidate novel therapeutic pathways targets, expression-based subclasses illness, discovery candidate diagnostic stratification biomarkers. Other disciplines are leading insights regarding pathobiology For example, neutrophil gelatinase-associated lipocalin early biomarker acute kidney injury is based trancriptomic proteomic involving animals models. Comparative led important signaling mechanisms relevant Toll-like receptor 4 primary for lipopolysaccharide product comparative genomics. Finally, epigenetics beginning provide clues why recovery may be associated prolonged risk subsequent Overall, genomics-centered continue evolve in field care medicine hold promise substantially advancing our understanding approach
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