Albumin stabilizes leukotriene A4.
作者： F A Fitzpatrick , D R Morton , M A Wynalda
DOI: 10.1016/S0021-9258(18)34575-7
关键词: Biochemistry 、 Aqueous solution 、 Eicosanoid 、 Amino acid 、 Chemistry 、 Kinetics 、 Reaction rate constant 、 Albumin 、 Leukotriene A4 、 Bovine serum albumin
摘要: Chemical analysis of intact leukotriene A4 showed that vertebrate albumins prolonged its aqueous half-life. At pH 7.4, hydrolyzed by first order reaction kinetics with rate constants inversely proportional to the albumin concentration. The stabilizing effect varied quantitatively among different species. Certain agents, such as warfarin, interact site I binding region reversed effect. Sequestration and exposure a hydrophobic, alkaline microenvironment would account for results. amino acid sequences Lys-Ala-Trp-Ala-Val-Ala-Arg from residues 211-217 human or Lys-Ala-Trp-Ser-Val-Ala-Arg 210-216 bovine are compatible this requirement. persistence in presence confirms extends our recent observations on uniform predictable influence eicosanoid stability. significance is uncertain; however, can no longer be viewed inert considering capacity modify stability several, structurally diverse eicosanoids.
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