Leukotriene A4-induced bronchoconstriction in the guinea pig in vivo.

摘要: Abstract Administration of leukotriene A4 (0.03 - 0.3 μg kg−1 i.v.) to anesthetized spontaneously breathing guinea pigs produced pronounced changes in pulmonary resistance, dynamic compliance and blood pressure. The responses were unaffected either by pretreatment with indomethacin or following desensitization B4 but significantly attenuated the D4 receptor antagonist, FPL-55712. Following administration increased levels C4-immunoreactive material determined plasma neutrophil accumulation was observed lung. It concluded that induced bronchoconstriction pig acting directly on site more probably through efficient metabolism lung peptido-lipid leukotrienes which turn exerted direct bronchoconstrictor actions.