Prospects for control of hepatitis B virus infection: implications of childhood vaccination and long-term protection.

摘要: Hepatitis B vaccine has been recommended for high-risk individuals in the United States more than a decade. This targeted strategy, however, failed to control hepatitis virus (HBV) infection. Universal immunization is being considered as an alternative approach, particular inclusion of with routine childhood vaccinations. Data presented herein demonstrate high degree efficacy immune globulin preventing perinatal HBV infection newborns. Immune response was dependent part on dose administered, some enhancement if infant older at time initial injection or booster given later. Long-term follow-up showed persistence vaccine-induced antibody 5 10 years 90% immunized infants and adults. Only 3% 5% these had serologic evidence None infections symptomatic none resulted chronic carrier state. Thus, responses were excellent, immunity protection against clinically significant persisted least years, features essential success program universal HBV.