Hydrodynamic modelling of protein conformation in solution: ELLIPS and HYDRO

摘要: The last three decades has seen some important advances in our ability to represent the conformation of proteins solution on basis hydrodynamic measurements. Advances theoretical modeling capabilities have been matched by commensurate precision We consider whole-body (simple ellipsoid-based) modeling—still useful for providing an overall idea molecular shape, particularly those systems where only a limited amount data is available—and outline ELLIPS suite algorithms which facilitates use this approach. then focus bead strategies, surface or shell–bead approaches and HYDRO algorithms. demonstrate how these are great insights into complex issues such as immunoglobulins other multi-domain complexes.