Erythropoietin restores glutathione peroxidase activity in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine-induced neurotoxicity in C57BL mice and stimulates murine astroglial glutathione peroxidase production in vitro.
作者： Sermin Genc , Mustafa Akhisaroglu , Filiz Kuralay , Kursad Genc
DOI: 10.1016/S0304-3940(02)00041-1
关键词: MPTP 、 Neuroprotection 、 Glutathione peroxidase 、 Glutathione 、 Erythropoietin 、 Substantia nigra 、 Endocrinology 、 Internal medicine 、 Superoxide dismutase 、 Neurotoxicity 、 Chemistry
摘要: Recently, we have reported that erythropoietin (Epo) provides neuroprotection in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-induced neurotoxicity vivo. In the present study, investigated effects of single Epo administration on brain antioxidant enzyme (superoxide dismutase (SOD) and glutathion peroxidase (GSHPx)) activities this model C57BL/6 mice. We found MPTP treatment decreased GSHPx activity both substantia nigra striatum, restores nigral by MPTP. SOD was not significantly changed treatment. Further, stimulated astroglial production neonatal murine cell culture suggesting possible source for stimulation MPTP-induced are astroglia. conclusion, modulation defense system might be one mechanisms which exerts a beneficial effect Parkinsonism.
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