Erythropoietin--a novel concept for neuroprotection.

摘要: Neuroprotection as a means to prevent or oppose pathological neuronal loss in central nervous system disease of various pathophysiological origins represents novel therapeutic approach. This approach is supported by extensive experimental evidence on cell culture and animal studies demonstrating beneficial effects growth factors survival functional recovery. The clinical use neuroprotective agents has been hampered the toxicity many compounds that showed promising potential studies. focus this review with erythropoietin, hematopoietic factor that: 1) expressed human system, 2) hypoxia-inducible, 3) demonstrated remarkable models disease, 4) multiple protective (antiapoptotic, neurotrophic, antioxidant, angiogenic), 5) clinically extremely well tolerated compound.